Issues

• Triage: which ODE solvers honour per-compartment tolerances? atolSens/rtolSens depend on it

  nlmixr2/rxode2#1411 · Filter by author mattfidler opened on Sep 28, 2026

• All of our checks are OK, but CRAN checks are failing

  nlmixr2/rxode2#1373 · Filter by author mattfidler opened on Sep 14, 2026
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• indLin: exploit the block-triangular structure of the rxSensMatExp() augmented system instead of exponentiating n(1+k) square

  nlmixr2/rxode2#1301 · Filter by author mattfidler opened on Aug 26, 2026

• indLin/meOnly(): count per-row heap allocations before optimizing -- the matExp value path is 2.3-2.7x the ODE integrator

  nlmixr2/rxode2#1300 · Filter by author mattfidler opened on Aug 26, 2026

• indLin: key the exponential cache on (parameter window, dt) rather than the operand bytes, so a hit skips the ME() rebuild

  nlmixr2/rxode2#1299 · Filter by author mattfidler opened on Aug 26, 2026

• No test drives the indLin per-thread pool fallback (ind_solve from an external OpenMP team)

  nlmixr2/rxode2#1247 · Filter by author mattfidler opened on Aug 13, 2026

• Flaky: test-oom.R mirai parallel= chunk intermittently fails with "model does not have correct model variables"

  nlmixr2/rxode2#1245 · Filter by author mattfidler opened on Aug 13, 2026

• _setThreadInd() copies a whole rx_solving_options_ind per generated-function call; profile its cost for indLin

  nlmixr2/rxode2#1244 · Filter by author mattfidler opened on Aug 13, 2026

• par_indLin() ignores rx->ordId, so parallel indLin gets no load balancing and a different seed offset from other drivers

  nlmixr2/rxode2#1243 · Filter by author mattfidler opened on Aug 13, 2026

• rxMemoryEstimate() does not account for per-thread solver workspaces (rwork, lsoda ctx, linCmtB, extra dosing)

  nlmixr2/rxode2#1242 · Filter by author mattfidler opened on Aug 13, 2026

• docs(indLin): restore the inductive-linearization material in the article

  nlmixr2/rxode2#1190 · Filter by author mattfidler opened on Aug 5, 2026

• Consider reproducing adaptive dosing of mrgsolve used by frex

  nlmixr2/rxode2#1291 · Filter by author mattfidler opened on Jun 29, 2026

• Add solved transit compartment model

  nlmixr2/rxode2#1099 · Filter by author mattfidler opened on Jun 29, 2026

• Add solved MM model

  nlmixr2/rxode2#1098 · Filter by author mattfidler opened on Jun 29, 2026

• Consider extending sticky variables to cover commonly calculated variables

  nlmixr2/rxode2#1097 · Filter by author mattfidler opened on Jun 29, 2026

• Consider extending adaptive dosing with common scenarios

  nlmixr2/rxode2#1096 · Filter by author mattfidler opened on Jun 29, 2026
  1

• Discussion: de-vendor the body-copied C helpers (sbuf, RSprintf, strncmpci, …) — or keep per-package copies?

  nlmixr2/rxode2#1080 · Filter by author billdenney opened on Jun 15, 2026

• Cross-package symbol collisions: consumer function-pointer globals share names with provider functions (RTLD_GLOBAL hazard)

  nlmixr2/rxode2#1079 · Filter by author billdenney opened on Jun 15, 2026

• Add DAE

  nlmixr2/rxode2#1066 · Filter by author mattfidler opened on Jun 6, 2026

• Add SDE

  nlmixr2/rxode2#1065 · Filter by author mattfidler opened on Jun 6, 2026

• Flag evid_() related functions as needing numeric derivatives

  nlmixr2/rxode2#1055 · Filter by author mattfidler opened on May 27, 2026

• scale parameter does not apply to endpoint

  nlmixr2/rxode2#988 · Filter by author danieleboaretti opened on Feb 27, 2026
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• Using dose in a model causes it to have a Symengine parse error

  nlmixr2/rxode2#935 · Filter by author billdenney opened on Sep 29, 2025
  3

• Add documentation of evid 5

  nlmixr2/rxode2#928 · Filter by author billdenney opened on Sep 4, 2025
  1

  

• Bad models

  nlmixr2/rxode2#917 · Filter by author mattfidler opened on Aug 14, 2025
  1