diff --git a/src/inspector_js_api.cc b/src/inspector_js_api.cc
index 09f0d7e84ce6..0821e8dfd555 100644
--- a/src/inspector_js_api.cc
+++ b/src/inspector_js_api.cc
@@ -132,6 +132,14 @@ class JSBindingsConnection : public BaseObject {
     Local<Value> argument;
     if (!ToV8Value(env()->context(), message, isolate).ToLocal(&argument))
       return;
+    // An in-process inspector channel delivers protocol messages by calling
+    // into JavaScript. Debugger.paused can be emitted from a V8
+    // RequestInterrupt handler, before V8 opens its own
+    // AllowJavascriptExecutionScope for the pause message loop. d8's inspector
+    // channel makes the same opt-out in InspectorFrontend::Send(). Messages
+    // emitted where calling into JavaScript is unsafe, such as GC callbacks,
+    // take the queueing path above instead.
+    Isolate::AllowJavascriptExecutionScope allow_js(isolate);
     OnMessage(argument);
   }
 
diff --git a/test/parallel/test-inspector-pause-with-js-session.js b/test/parallel/test-inspector-pause-with-js-session.js
new file mode 100644
index 000000000000..b509d30c125f
--- /dev/null
+++ b/test/parallel/test-inspector-pause-with-js-session.js
@@ -0,0 +1,53 @@
+'use strict';
+const common = require('../common');
+
+common.skipIfInspectorDisabled();
+
+const assert = require('assert');
+const { NodeInstance } = require('../common/inspector-helper.js');
+
+// An in-process session observes Debugger.paused while the process is paused,
+// so its callback runs from the Isolate::RequestInterrupt handler that
+// Debugger.pause schedules, where V8 asserts that JS is not executed.
+const script = `
+const { Session } = require('inspector');
+const session = new Session();
+let paused = false;
+session.on('Debugger.paused', () => {
+  paused = true;
+});
+session.connect();
+session.post('Debugger.enable');
+console.log('Ready');
+// Spin so that the pause is requested while JS is on the stack, which is what
+// makes V8 break from the interrupt handler instead of on the next call.
+const deadline = Date.now() + ${common.platformTimeout(10000)};
+while (!paused && Date.now() < deadline);
+console.log(paused ? 'Notified' : 'Not notified');
+`;
+
+async function runTest() {
+  const child = new NodeInstance(undefined, script);
+  const session = await child.connectInspectorSession();
+  await session.send({ method: 'NodeRuntime.enable' });
+  await session.waitForNotification('NodeRuntime.waitingForDebugger');
+  await session.send([
+    { 'method': 'Runtime.enable' },
+    { 'method': 'Debugger.enable' },
+  ]);
+  await session.send({ method: 'Runtime.runIfWaitingForDebugger' });
+  await session.send({ method: 'NodeRuntime.disable' });
+  await session.waitForNotification('Debugger.paused', 'Break on start');
+  await session.send({ 'method': 'Debugger.resume' });
+  await session.waitForConsoleOutput('log', ['Ready']);
+
+  await session.send({ 'method': 'Debugger.pause' });
+  await session.waitForNotification('Debugger.paused', 'Paused');
+  await session.send({ 'method': 'Debugger.resume' });
+  await session.waitForConsoleOutput('log', ['Notified']);
+
+  await session.waitForDisconnect();
+  assert.strictEqual((await child.expectShutdown()).exitCode, 0);
+}
+
+runTest().then(common.mustCall());