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## Date

2026-08-07

## Authors

- [Mahdi Loutfi](/team/mahdi-loutfi)
- [Martin Vallières](/team/martin-vallieres)

## Summary

**Purpose**: Clinical translation of radiomics is hindered by the high-dimensional feature sets and lack of accessible tools for clinicians. MEDiml, an open-source platform designed to help democratize the development of radiomics models by identifying the simplest predictive features through both a code-based and graphical interface.

**Methods**: MEDiml was evaluated using 89,714 features from five oncological datasets (n=2,104). Tasks included histology subtype prediction for non-small cell lung cancer (NSCLC, MRI); renal cell carcinoma (RCC, MRI); and RCC (contrast-enhanced CT); IDH1 mutation prediction for low-grade glioma (LGG, MRI); and grade prediction for meningioma (MRI). For modeling, features are categorized by complexity (morphological, intensity, texture, linear/nonlinear filters) for XGBoost training. The pipeline cleans invariants and filters collinearity, retaining only features highly correlated with clinical endpoints.

**Results**: We released the MEDiml software with detailed documentation (mediml.app). Evaluation demonstrated that maximum predictive performance does not always require high-complexity features. Optimal levels were: morphological for LGG-IDH1 and Meningioma-grading; intensity in NSCLC and RCC -CECT; and texture for RCC-MRI. In the RCC-CECT cohort, optimizing the re-segmentation range, a parameter for excluding non-target voxels affecting intensity features, improved performance from an AUC of 0.82 to 0.86.

**Conclusion**: MEDiml successfully identifies the "optimal complexity level" for specific clinical outcomes, demonstrating that simpler models can often match or exceed the performance of high-dimensional sets. By providing an interactive, user-friendly interface and a strategy for feature minimization, MEDiml lowers the barrier to entry for clinicians, providing a scalable pathway for the clinical integration of radiomic biomarkers.

## Links

- [Primary link](NA)

## BibTeX

```bibtex

```
10 changes: 10 additions & 0 deletions src/data/publications.json
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"type": "Journal Papers",
"date": "2026-02-25"
},
{
"title": "Simpler Radiomics Can Be Enough: Identifying the Minimal Feature Complexity Required for Accurate Prediction",
"slug": "simpler-radiomics-can-be-enough-identifying-the-minimal-feature-complexity-required-for-accurate-prediction-2026",
"contributors": ["Mahdi Loutfi", "Martin Vallières"],
"journal": "Lady Davis Institute (LDI) Conference (Poster Presentation)",
"link": "NA",
"markdown": "publications/simpler-radiomics-can-be-enough-identifying-the-minimal-feature-complexity-required-for-accurate-prediction-2026.md",
"type": "Presentations",
"date": "2026-08-07"
},
{
"title": "Kaféfak Presentation - First Publication Award",
"slug": "kafefak-presentation-first-publication-award-2026",
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