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barmanios123/README.md

Hi, I'm Beshoy 👋

PhD in Pharmacology & Toxicology (UConn) and MPH (UMass Chan Medical School). I work where molecular pharmacology meets data: RNA therapeutics, liver noncoding RNA biology in MASLD, drug safety, and the software that makes that science easier to use.

Research interests: oligonucleotide therapeutics (ASO, siRNA) · lncRNA biology in MASLD/MASH · toxicology and drug safety · translational PK/PD · public health · AI in medicine


Featured projects

Project What it does Stack
OligoTox Mechanism-aware toxicity scoring and candidate triage for oligonucleotide therapeutics, with PK/PD context and regulatory-style reports Python · scikit-learn · FastAPI · Streamlit
Liver ncRNA Translational Engine Ranks liver noncoding RNA targets in MASLD/MASH, fibrosis, and HCC with evidence-typed target dossiers built from public GEO cohorts Python · SQLite · Streamlit
Drug Target Explorer ETL and REST API over Open Targets data that ranks drugs for a gene target by specificity and adverse-event burden Python · FastAPI · SQLite
mps-pkpd-methods Links microphysiological-system (liver chip) APOC3 knockdown data to exposure–response models R
generalized_heatmap_batch.R Batch heatmaps from differential expression results R

Building now

MoveGuard: a free, mobile-first app that helps renters take time-stamped move-in and move-out photos, so deposit disputes come down to records instead of memory. Next.js · FastAPI · Postgres.


Connect

LinkedIn · X / Twitter

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  1. OligoTox OligoTox Public

    Oligonucleotide toxicity prediction platform — ML pipeline, FastAPI + Streamlit app, curated safety dataset

    Python 1

  2. drug-target-explorer drug-target-explorer Public

    ETL + FastAPI over Open Targets data that ranks drugs for a gene target by specificity and adverse-event burden

    Python

  3. Liver-ncRNA-Translational-Engine Liver-ncRNA-Translational-Engine Public

    Ranks liver noncoding RNA targets in MASLD/MASH, fibrosis, and HCC with evidence-typed dossiers from public GEO cohorts. Streamlit dashboard.

    Python

  4. mps-pkpd-methods mps-pkpd-methods Public

    R workflows linking liver-chip (MPS) APOC3 knockdown data to Emax exposure-response and toy PK/PD translation models

    R