Probe and cluster antibody paratopes and clonotypes
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Updated
Oct 2, 2023 - Python
Probe and cluster antibody paratopes and clonotypes
Structural bioinformatics pipeline for clustering antibody-antigen epitopes by geometric similarity and deriving consensus paratope design constraints for antibody engineering.
Group antibodies by the binding site they present, not by sequence. Predicts which CDR residues actually contact antigen, then clusters antibodies on those residues to surface clonally unrelated antibodies that converged on the same binding mode
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